Debomoy Lahiri, Bryan Maloney on Epigenetic Shenanigans—In AD, Chromatin Opens Up in Blood Immune Cells
COMMENT comments already posted in Alzforum. We have long maintained that there is an important role for epigenetic
6 RESULTS
COMMENT comments already posted in Alzforum. We have long maintained that there is an important role for epigenetic
COMMENT Hats off to the authors for illumiNATing NATs. Maintaining cellular checks and balances requires multiple mechanisms. A recently reported participant to maintain tau protein homeostasis was mammalian-wide interspersed repeat (MIR) natural antisense transc
COMMENT Alzforum and elsewhere (Lahiri, Maloney, et al., comment on Liver Tox Ends Janssen BACE Program, 2014;
COMMENT et al., 2014; Feb 2017 comment). We propose trying a selective BACE1 inhibition to tackle the
COMMENT Merck pushing forward on clinical trials for a BACE1 inhibitor in such late stages of AD is certainly puzzling, as others have already noted. It is to be expected that, once Aβ has plateaued and sufficient Aβ-related damage has been done, there will be li
COMMENT Lilly’s BACE1 inhibitor trial is off-base but not off-target. The amyloid β-site cleaving enzyme (BACE1), which is the rate-limiting enzyme in the pathway that produces amyloid-β peptide (Aβ) from the Aβ precursor protein (APP) (Vassar et al., 1999), is c